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Fig. 6 | Gut Pathogens

Fig. 6

From: Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD+ salvage metabolic pathway

Fig. 6

NR replenishment, but not SIRT1 overexpression, completely corrected the progression of ALF induced by F. nucleatum infection. a Representative images of HE staining and infiltrated monocytes by F4/80 and CD68 immunofluorescence staining in liver tissues of each group and quantified in (d, e). *P < 0.05. n = 6 for each group. b Effect of SIRT1 overexpression or NR on expression of the pro-inflammatory factors TNF-α and IL-1β in liver tissues and quantified in (f). *P < 0.05. n = 6 for each group. c Western blotting was performed to measure the expression of SIRT1 in liver tissues treated with SIRT1 overexpression or NR in mice infected with F. nucleatum and quantified. Data shown are means ± SD of three separate experiments. *P < 0.05; one-way ANOVA combined with Bonferroni's post hoc test; the error bars indicate the SDs

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Gut Pathogens

ISSN: 1757-4749