Fig. 11

Effect of CDDP treatment on tight junction proteins (TJs) expression in the colon epithelium. A The relative expression of Occludin and Claudin-1 in STZ-induced T1DM mice were analyzed by western blotting technique after 4-weeks treatment using β-actin as an internal control. Western blots are the representative of three experiments. B Bar graph represent the intensity of relative protein band against β-actin as an internal control, quantified by NIH image J software. Data obtained from three experiments are presented as Mean ± SEM (n = 6). * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.001, model group compared with control group and CDDP and metformin treatment groups compared with model group