Fig. 7

Quantification of pro-inflammatory cytokines levels in STZ-induced T1DM mice. The analysis was carried out after the oral administration of CDDP and Metformin for 4-weeks. Levels of: A IL-1β, B IL-2, C IL-6, D TNF-α, and E IFN-γ by ELISA were determined at the end of the experiment. Data were represented as Means ± SEM (n = 6), evaluated by one-way ANOVA by Tukey’s Multiple Comparison Test. # p < 0.05, ## p < 0.01 and ### p < 0.001, model group compared with control group * p < 0.05, ** p < 0.01 and *** p < 0.001, CDDP and metformin treatment groups compared with model group