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Fig. 6 | Gut Pathogens

Fig. 6

From: Hypoxia exacerbates intestinal injury and inflammatory response mediated by myeloperoxidase during Salmonella Typhimurium infection in mice

Fig. 6

Hypoxia aggravates inflammatory response in MPO-deficient mice during Salmonella infection. Under the condition of Salmonella infection with normal MPO function, MPO played a bactericidal role. Under hypoxic exposure and MPO-deficient conditions, massive H2O2 releases and massive recruitment of neutrophils and macrophages lead to a dramatic increase in ROS, causing decreased oxidative capacity and overexpression of inflammatory genes

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Gut Pathogens

ISSN: 1757-4749