Fig. 1

Network inferred for HC samples using SPIEC-EASY algorithm for OTUs collated at genus level. The size of the nodes in the network corresponds to Integrated View of Influence scores whilst the nodes are colored at Phylum level. Left panel shows the top 20 important nodes along with their scores based on composite measure Integrated View of Influence, along with the Spreading Score and the Hubness Score. To improve clarity, bars of nodes that were not in top 20 list for a given metric were not drawn. These influential genera (n = 25) are then annotated on the network figure shown in the middle panel