Fig. 5

Lower gastrointestinal FMT can reduce the levels of F. nucleatum (shown as nusG gene) and virulence fadA, and the levels of F. nucleatum and virulence fadA are negatively correlated with FMT therapeutic times. A, The Correlation heatmap reveals the correlation between inflammatory cytokines TNF-α, IL-1β, IL-6, and the top 50 genera in abundance among the five groups. B, Correlation heatmap among OR, UFMT, and LFMT groups. C, The changes of nusG gene level with the increased times of FMT among groups. D, The changes of fadA gene level with the increased times of FMT among groups. E, Fecal nusG level was negatively correlated with FMT times (r = 0.9531, p<0.001). F, Fecal fadA level was negatively correlated with FMT times (r = 0.9610, p<0.001). C, D, Data are presented as mean ± SD, p values were determined by analysis of variance, *p<0.05, **p<0.01 vs. OR, ^##p<0.01 vs. LFMT. E, F, and Data are performed by Spearman correlation