Fig.4

Microbiome-Immune interactions in the pathogenesis of infection- The correlation network represents the pairwise Spearman correlation analysis of the obtained fecal bacterial products (Fig. 1), inflammatory markers (Fig. 2), gut integrity and bacterial translocation markers (Fig. 3) with each other and with relative abundance of bacterial taxa of all the study participants and relative frequencies of immune subsets in HCMV infected infants with NC reported in the previous study [14]. Red lines indicate a positive correlation and blue indicates a negative correlation. The strength of the correlation is indicated by the intensity of the color of the lines in the network. Only the significant correlations have been plotted. The coloured boxes indicate the following: Orange- Relative abundance of bacterial taxa; Pink- Relative frequencies of immune cell subsets; Green-Fecal microbial products; Yellow- Fecal inflammatory markers; Purple- Fecal Gut integrity markers; (A) Granzyme B expressing cells regulatory network; (B) T cell compartment regulatory network; (C) Leaky gut network; (D) Inflammatory cascade network