Fig. 5

COG and KEGG functional prediction based on fecal 16S RNA sequencing. A Heatmap of differential clusters of orthologous groups of proteins (COGs) between HBs-HepR mice and B6-HepR mice (top 15). A bar showing the diffserential clustering of COG and mean proportions are shown for HBs-HepR mice and B6-HepR mice. B Heatmap of differential pathways of Kyoto Encyclopedia of Genes and Genomes (KEGG) at level 3 between HBs-HepR mice and B6-HepR mice (top 15). The bars of differential pathways and the mean proportions are shown. PICRUSt2 (2.3.0b0) was used. Statistical analysis was performed with the Wilcoxon signed-rank test