Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts

Table 3 Differentially abundant genera in PDAC common to both populations

	Genus^a	Change^b	Taxonomy (phylum/class)	Occurrence^c
1	Sellimonas	+	Firmicutes/Clostridia	Unique to PDAC vs. HC in both populations
2	Veillonella	+	Firmicutes/Negativicutes
3	Klebsiella	+	Proteobacteria/Gammaproteobacteria
4	Eisenbergiella	+	Firmicutes/Clostridia
5	Fusobacterium	+	Fusobacteriota/Fusobacteriia
6	Enterobacter	+	Proteobacteria/Gammaproteobacteria
7	Unknown Enterobacterales	+	Proteobacteria/Gammaproteobacteria
8	[Clostridium] innocuum group	+	Firmicutes/Clostridia
9	Unknown Enterobacteriaceae	+	Proteobacteria/Gammaproteobacteria
10	Anaerotruncus	+	Firmicutes/Clostridia
11	Lachnoclostridium	+	Firmicutes/Clostridia
12	Butyricicoccaceae UCG-009	−	Firmicutes/Clostridia
13	Clostridia UCG-014	−	Firmicutes/Clostridia
14	Coprobacillus	+	Firmicutes/Bacilli	In PDAC vs. HC in both populations In IPDAC vs. FPDAC
15	Cloacibacillus	+	Synergistota/Synergistia
16	Unknown Gammaproteobacteria	+	Proteobacteria/Gammaproteobacteria
17	Kluyvera	+	Proteobacteria/Gammaproteobacteria
18	Bacteroides	+	Bacteroidota/Bacteroidia
19	Asteroleplasma	−	Firmicutes/Bacilli
20	Enterococcus	+	Firmicutes/Bacilli	In PDAC vs. HC in both populations In IPDAC vs. FPDAC In IHC vs. FHC
21	Erwinia	+	Proteobacteria/Gammaproteobacteria
22	Flavonifractor	+	Firmicutes/Clostridia
23	Succinivibrio	+ / −	Proteobacteria/Gammaproteobacteria
24	Hungatella	+	Firmicutes/Clostridia	In PDAC vs. HC in both populations In IHC vs. FHC
25	Rikenellaceae RC9 gut group	+ / −	Bacteroidota/Bacteroidia	In PDAC vs. HC in both populations In IHC vs. FHC

^aIn descending order of fold differences
^bIndicates significantly higher (+) or lower (−) abundance in PDAC in both populations
^cSee also Venn diagram, Fig. 5C
FHC, Finnish HC; FPDAC, Finnish PDAC; HC, healthy control; IHC, Iranian HC; IPDAC, Iranian PDAC; PDAC, pancreatic ductal adenocarcinoma

ISSN: 1757-4749